Compositions and methods of treating abnormal cell proliferation
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United States of America Patent
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Apr 22, 2003
Grant Date -
Dec 6, 2001
app pub date -
Jun 1, 2001
filing date -
Jul 16, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A composition is described comprising a vitamin D analog and a retinoid wherein: (a) the vitamin D analog is capable of binding a vitamin D receptor or being converted in vivo into a compound capable of binding a vitamin D receptor; and (b) the retinoid is selected from the group consisting of retinol in a concentration of at least about 1.0% and a retinoid characterized by having a substitution at the 4-position. Further, methods of treating disorders characterized by abnormal cell-proliferation and/or cell-differentiation are also described.
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