Function-based small molecular weight compound screening system in drosophila melanogaster
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United States of America Patent
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Apr 15, 2003
Grant Date -
Feb 28, 2002
app pub date -
Dec 21, 1998
filing date -
Dec 21, 1998
priority date (Note) -
Expired
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Abstract
A methodology for screening libraries of compounds for desirable biological/therapeutic activities, preferably using an automated system for the microinjection of compound(s) of interest into the open circulatory system (i.e., hemolymph) of Drosophila larvae genetically modified to sensitize a particular signaling pathway related to a human disease either by expression of a human disease gene or by the activation of a Drosophila gene that in the adult fly results in the development of an easily detectable phenotypes such that compounds that selectively interfere with this specific signaling pathway will modify or suppress the phenotype and can be identified rapidly and efficiently.
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