Process for producing isocoumarins and intermediates for the same
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United States of America Patent
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Apr 15, 2003
Grant Date -
Oct 10, 2002
app pub date -
Apr 11, 2002
filing date -
Jul 22, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by a formula: ##STR1## (wherein R.sub.c, R.sub.2 and R are mainly protecting groups) with a malonic acid derivating represented by a formula: ##STR2## (wherein R is an organic group including a lower alkyl group; R.sub.3 is a protecting group for a carboxyl group; and X is a halogen atom or a --OM group (wherein M is alkaline metal or alkaline earth metal)). According to the above process, various isocoumarin-3-yl-acetic acid derivatives can efficiently be provided.
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