Peptoid and nonpeptoid containing .alpha.-keto oxadiazoles as serine protease inhibitors
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United States of America Patent
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Apr 15, 2003
Grant Date -
Jan 24, 2002
app pub date -
Apr 26, 2001
filing date -
Jun 3, 1998
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Expired
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Abstract
The present invention relates to certain substituted oxadiazole peptoids and nonpeptoids useful as inhibitors of serine proteases, especially human neutophil elastase (HNE). Compounds of the present invention are useful for the treatment or amelioration of symptoms of adult respiratory distress syndrome, septic shock, and multiple organ failure. Processes mediated by HNE are also implicated in conditions such as arthritis, periodontal disease, glomerulonephritis, and cystic fibrosis.
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