Macrophage derived chemokine (MDC) as an anti-viral agent for the treatment and prevention of lentivirus infection
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United States of America Patent
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Apr 15, 2003
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N/A
app pub date -
Sep 16, 1997
filing date -
Sep 16, 1997
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Expired
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Abstract
The present invention relates to therapeutic compositions of macrophage derived chemokine (MDC) and methods for treating and preventing infection by a lentivirus, particularly an immunodeficiency virus, particularly HIV, using MDC proteins, nucleic acids and/or derivatives or analogues thereof. The present invention further relates to methods for detection and prognosis of lenivirus infection, particularly HIV infection using MDC as a prognostic indicator. The present invention further provides MDC proteins, nucleic acids encoding such proteins, that have amino-terminal sequences that differ from other MDC isolates. Recombinant host cells and methods of production are also provided.
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