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Abstract

Use of a compound of formula (I): ##STR1## wherein X is optionally substituted aminoalkyl, optionally substituted alkylene or an interactive group; Y and Z may be the same or different and are selected from N, O, S and C(R') wherein R' is hydrogen, optionally substituted alkyl or optionally substituted alkenyl; ---- is a double bond unless the attached Y or Z group is O or S in which case it is a single bond; and R.sub.1 to R.sub.11 may be the same or different and are selected from hydrogen, a sterically hindering group and an electron donating group; or any two of R.sub.1 to R.sub.11, Y, Z, NH and R' may together with the carbon atoms to which they are attached form an optionally substituted ring which may contain heteroatoms, provided that at least one of R.sub.1 to R.sub.11 is an electron donating group and that when X is NCH.sub.3, Y and Z are N and R.sub.1, R.sub.2 and R.sub.4 to R.sub.11 are hydrogen, then R.sub.3 is not OH or OCH.sub.2 CH.sub.3 ; and salts thereof, pharmaceutically acceptable derivatives thereof, pro-drugs thereof and/or tautomers thereof, as a radioprotector. Also provided is a method of protecting a subject from radiation damage, a method of protecting biological materials from damage caused by radiation or cytotoxic agents and certain novel compounds of formula (I). Processes for the preparation of the novel compounds of formula (I) are also provided.

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First Claim