Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
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United States of America Patent
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Apr 15, 2003
Grant Date -
Mar 14, 2002
app pub date -
May 31, 2001
filing date -
Dec 24, 1997
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Abstract
Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5(10)-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecular moiety which renders the compounds effective to competitively block the binding of estrogen to its receptor. Particularly preferred compounds are 17-desoxy-1,3,5(10)-estratrienes. Therapeutic methods and pharmaceutical compositions are provided as well.
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