Protein crystal structure and method for identifying protein modulators
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United States of America Patent
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Apr 8, 2003
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N/A
app pub date -
Mar 27, 2001
filing date -
Mar 27, 2001
priority date (Note) -
Expired
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Abstract
A method of identifying an agent compound (such as an inhibitor) which modulates asparate decarboxylase (ADC) activity. The method comprises the steps of: a) providing a model of a binding cavity of ADC, said model including at least one of binding site nos. 1 and 9 defined by Table 2; b) providing the structure of said agent compound; c) fitting the candidate agent compound to said binding cavity, including determining the interactions between the candidate agent compound and at least one of binding site nos. 1 and 9; and d) selecting the candidate agent compound.
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