Methods for detecting prostate stem cell antigen protein
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United States of America Patent
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Apr 1, 2003
Grant Date -
Dec 27, 2001
app pub date -
May 3, 2000
filing date -
Mar 10, 1997
priority date (Note) -
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Abstract
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. The invention also provides a method for detecting a Prostate Stem Cell Antigen (PSCA) protein of bone (SEQ ID NO:2), comprising obtaining a sample; contacting the sample with an antibody that recognizes and binds the PSCA protein; and, detecting binding of the antibody with the PSCA protein in the sample.
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