Method and means for the production of hyaluronic acid
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United States of America Patent
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Mar 25, 2003
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app pub date -
Feb 1, 2000
filing date -
May 26, 1994
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Abstract
A method for selecting streptococcus strains capable of producing hyaluronic acid with molecular weight exceeding six million includes the steps of cultivating strains of streptococci individually in culture medium which is free of metal ions which promote degradation of hyaluronic acid and which does not release from the reactor metal ions which promote the degradation of hyaluronic acid; and selecting a supercapsulated strain of a streptococcus, supercapsulated members thereof having a mucoid morphology and being capable of forming capsules having a diameter of greater than 4 .mu.m.
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