Vaccina virus comprising cytokine and/or tumor associated antigen genes
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United States of America Patent
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Mar 25, 2003
Issued Date -
N/A
app pub date -
Mar 24, 2000
filing date -
Mar 8, 1989
priority date (Note) -
Expired
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Abstract
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least on of: human tumor necrosis factor; nuclear phosphoprotein p53, wildtype or mutant; human melanoma-associated antigen; IL-2; IFN.gamma.; IL-4; GNCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
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