Fibrate-statin combinations with reduced fed-fasted effects
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United States of America Patent
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Mar 18, 2003
Grant Date -
Oct 31, 2002
app pub date -
Apr 20, 2001
filing date -
Feb 22, 2001
priority date (Note) -
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Abstract
This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilized by phospholipid as a surface active substance, wherein a therapeutically effective amount of the composition provides the statin and a quantity of fenofibrate to a fasted human patient that is greater than 80% of the quantity of fenofibrate provided by the same amount of the composition when administered to the same patient who has been fed a high fat meal.
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