Method for administering camptothecins via injection of pharmaceutical composition comprising coated particles of a camptothecin
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United States of America Patent
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Mar 18, 2003
Grant Date -
Oct 10, 2002
app pub date -
Feb 12, 2001
filing date -
Feb 12, 2001
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Abstract
A method for administering a camptothecin to a patient comprising: injecting into a patient a pharmaceutical composition comprising an aqueous suspension of solid particles suitable for intravenous delivery, the solid particles comprising a camptothecin, and a 0.3 nm to 3.0 .mu.m thick layer of a membrane-forming amphipathic lipid wherein the solid particles have mean diameters between about 0.05 .mu.m and 10 .mu.m. The method is particularly well suited for delivering camptothecins, particularly 9-nitro-camptothecin intravenously.
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