Drug delivery system for enhanced bioavailability of hydrophobic active ingredients

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United States of America Patent

PATENT NO 6531158
SERIAL NO

09635234

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Abstract

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The present invention provides a drug delivery system for the oral administration of a hydrophobic active ingredient. The active ingredient's post-ingestion dissolution rate and its corresponding bioavailability can be optimized by intimately mixing a micronized hydrophobic drug with suitably sized inert particles to a dispersion that will facilitate desired bioavailability. In a particular embodiment, the hydrophobic active ingredient is fenofibrate. Suitably sized inert particles include microcrystalline cellulose and lactose. Dispersion may be monitored by microscopic visualization.

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Patent Owner(s)

Patent OwnerAddress
IMPAX LABORATORIES INC30831 HUNTWOOD AVENUE HAYWARD CA 94544

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gatts, Joshua Hayward, CA 2 9
Hsiao, Charles Livermore, CA 21 861
Teng, Ching-Ling Fremont, CA 2 9

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