High throughput HPLC method for determining Log P values
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United States of America Patent
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Feb 25, 2003
Grant Date -
N/A
app pub date -
Jul 26, 2000
filing date -
Aug 4, 1999
priority date (Note) -
Expired
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Abstract
Methods for calculating Log P values for organic compounds are disclosed. The methods allow identification of compounds in a library with a desired Log P value. The method can be used to minimize the number of compounds in a given combinatorial or lead generation library which need to be further characterized and/or assayed. The Log P value is preferably obtained while the purity of the compounds is being determined. Preferably, the Log P value is correlated to the retention time on an HPLC column, such that the retention time equals the Log P value.
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