Agent for preventing and curing hindrance of ischemic reperfusion
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United States of America Patent
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Feb 11, 2003
Grant Date -
Sep 12, 2002
app pub date -
Nov 14, 2001
filing date -
Feb 6, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: ##STR1## [wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 independently denote a hydrogen atom or a lower alkyl group, R.sup.5 denotes a hydrogen atom, a lower alkyl group, or a lower acyl group, X denotes a monosaccharide residue or an oligosaccharide residue which may have a lower alkyl group or a lower acyl group substituted for the hydrogen atom of the hydroxyl group of the saccharide residue, n denotes an integer of 0-6, and m denotes an integer of 1-6]. The agent, even in a small dosage, acts safely and effectively on the affected part and allows the hindrances of ischemic reperfusion induced in heart, stomach, small intestine, liver, spleen, kidney, brain, and skin, and the hindrance induced during the transplantation of an internal organ to be prevented and cured.
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