Nitrophenylaziridine compounds and their use as prodrugs
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United States of America Patent
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Feb 11, 2003
Grant Date -
N/A
app pub date -
Mar 6, 2001
filing date -
Sep 7, 1998
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Expired
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Abstract
A range of aziridin-1-yl nitrobenzamides are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2-substituents which may be bulky and polar. For example, 5-(aziridin-1-yl)-N-[2-(4-morpholino)ethyl]-2,4-dinitrobenzamide of Formula (A) was found to be highly active against all NR+ cell lines tested.
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