Delivery of nucleotides by electrochemical release
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United States of America Patent
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Feb 4, 2003
Grant Date -
N/A
app pub date -
Apr 21, 2000
filing date -
Apr 23, 1999
priority date (Note) -
Expired
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Abstract
An apparatus and method for controlled release of nucleotides from electrodes utilizing potential difference for use in delivering the nucleotide into an organism. The frequency, duration and rate of release may be specifically controlled to obtain optimal release of the nucleotide. The apparatus and method may be used in conjunction with methods for electroporation, wherein the nucleotide may transit the cell membrane, and move into the cell. Alternatively, the apparatus and method may be used in conjunction with complexes of DNA and lipids or other carriers, which complexes will transit the cell membrane and move into the cell. The apparatus and method may be used for gene therapy, for use in treatment of any of a wide variety of diseases.
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