Bioadhesive hydrogels with functionalized degradable crosslinks
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United States of America Patent
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Feb 4, 2003
Grant Date -
Jun 6, 2002
app pub date -
May 21, 1999
filing date -
May 21, 1999
priority date (Note) -
Expired
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Abstract
This invention relates to A bioadhesive composition comprising two or more essentially excretable, essentially non-degradable polymer backbones, wherein the polymer backbones are crosslinked, said crosslink being degradable in a mammal, said cross-linked bioadhesive composition having an average bioadhesion factor showing bioadhesion equivalent to at least about 100 g s. The concept is to build a hydrogel that demonstrates bioadhesion to a mucosal surface that is crosslinked by a degradable linkage such as disulfide for use inside the body.
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