Carrier particles for drug delivery and process for preparation
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Feb 4, 2003
Grant Date -
N/A
app pub date -
Feb 14, 2000
filing date -
Feb 14, 2000
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
This invention relates to a carrier particle having a diameter of from 5 to 20 nm which contains an HDL apolipoprotein, an amphipathic lipid such as a phospholipid, and a drug which is either a hydrophobic drug, amphipathic drug, or a cationic hydrophilic drug. The carrier particle is formed by a process in which the components are co-sonicated in a buffer. The apolipoprotein is preferably apo A-I or apo A-II. The carrier particle is particularly useful for increasing plasma circulation time of a hydrophobic drug relative to conventional hydrophobic drug carrier particles. Thus, drug efficacy is improved and toxicity of the drug to renal and reticuloendothelial tissues is reduced. A composition for drug delivery comprises the carrier particle suspended in a pharmaceutically acceptable medium, and is particularly suited to administration by parenteral infusion, systemic injection, transdermal patch, oral tablet or oral spray.
First Claim
Family