Synthesis of taxol, taxol analogs and their intermediates with variable a-ring side chain structures and compositions thereof
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United States of America Patent
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Jan 21, 2003
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N/A
app pub date -
May 22, 2001
filing date -
Feb 5, 1993
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Expired
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Abstract
The present invention relates to chemical compounds that are useful in the production of taxanes. The chemical compounds according to the present invention have a generalized formula: ##STR1## wherein R.sup.1 is .sup.+ NH.sub.3 X.sup.- where X is deprotonated organic acid such as deprotonated trifluoroacetic acid, and wherein R.sup.2 may be acetyl or hydrogen, and P.sup.1 may be hydrogen or a hydroxyl protecting group, such as benzyloxymethyl.
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