Cross-linked antibodies and processes for their preparation
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United States of America Patent
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Jan 21, 2003
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N/A
app pub date -
Jan 13, 1994
filing date -
Feb 10, 1989
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Expired
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Abstract
Bis-maleimido cross-linking reagents join labelled antibodies having at least one sulphide interchain bridge. The conjugates have an enhanced binding capacity and have good blood clearance in vivo. The conjugates are of use in the diagnosis and therapy of tumors and may be prepared by reaction of the cross-linking reagent with the antibody.
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