Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof
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United States of America Patent
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Jan 21, 2003
Grant Date -
May 2, 2002
app pub date -
Aug 31, 2001
filing date -
Apr 4, 1997
priority date (Note) -
Expired
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Abstract
The present invention provides a novel sustained release composition and method for making such a composition of diclofenac and its pharmaceutically acceptable salts. The composition of the present invention provides a sustained release formulation of diclofenac and pharmaceutically acceptable salts thereof which is suitable for once daily administration and provides controlled and long lasting in vivo release. The composition comprises: (a) about 5-25% by weight of hydroxyethyl cellulose; (b) about 5-75% by weight of lactose; (c) about 0-3% by weight of silicone dioxide; (d) about 0.5-5% by weight of PVP; (e) about <3% by weight of talc; and f) about <3% by weight of magnesium stearate.
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