Injectable pharmaceutical composition comprising coated particles of camptothecin
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United States of America Patent
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Jan 21, 2003
Grant Date -
Oct 3, 2002
app pub date -
Feb 12, 2001
filing date -
Feb 12, 2001
priority date (Note) -
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Abstract
A pharmaceutical composition is provided which comprises an aqueous suspension of solid particles, the solid particles comprising a camptothecin, the solid particles having mean diameters between about 0.05 um and 10 um, the particles coated with a 0.3 nm to 3.0 um thick layer of a membrane-forming amphipathic lipid. The pharmaceutical composition is particularly well suited for delivering camptothecins, particularly 9-nitro-camptothecin intravenously.
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