Process to manufacture simvastatin and intermediates
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United States of America Patent
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Jan 14, 2003
Grant Date -
N/A
app pub date -
Apr 24, 2001
filing date -
Jun 18, 1998
priority date (Note) -
Expired
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Abstract
A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
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