Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
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United States of America Patent
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Jan 7, 2003
Grant Date -
Sep 5, 2002
app pub date -
Dec 20, 2001
filing date -
May 22, 1995
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Expired
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Abstract
This invention relates to fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. An embodiment of the invention embraces compounds of the formula I: ##STR1## and the pharmaceutically tolerated salts thereof. The disclosed compounds are valuable inhibitors of the cellular sodium/proton exchanger (Na.sup.+ /H.sup.+ exchanger) . They are therefore outstandingly suitable for the treatment of all diseases attributable to increased Na.sup.+ /H.sup.+ exchange.
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