Adeno-associated virus capsid immunologic determinants
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United States of America Patent
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Dec 24, 2002
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app pub date -
May 28, 1999
filing date -
May 28, 1999
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Abstract
Polypeptides of adeno-associated virus (AAV) that bind to AAV antibodies or block binding of AAV to mammalian cells are described. Derivatives of peptides can be less immunogenic, enhance binding to cells, render a virus tissue specific and so on. The nucleic acid sequence encoding those derivatives can be incorporated into a capsid encoding sequence to enable a virus to express such a derivative and be less immunogenic, have enhanced transduction efficiency or be tissue specific.
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