Pharmaceutical composition for treating or preventing influenza, and novel capped oligonucleotide
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Dec 17, 2002
Issued Date -
N/A
app pub date -
Jun 26, 2000
filing date -
Dec 26, 1997
priority date (Note) -
Expired
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Abstract
A pharmaceutical composition comprising a capped oligonucleotide capable of binding to a PB2 protein of an influenza virus RNA polymerase, and a pharmaceutically acceptable carrier or dilute, said capped oligonucleotide having a structure of the formula (I): m.sup.7 GpppXpY (I) wherein ppp is a triphosphate bridge, p is a monophosphate bridge, m.sup.7 G is 7-methylguanosine group binding at 5' end thereof to said ppp, X is a 2'-O-methyl guanosine group or guanosine group, said 2'-O-methyl guanosine group or guanosine group binds at a 5' end thereof to said ppp, and at a 3' end thereof to said p, and Y is an oligoribonucleotide moiety binding at 5' end thereof to said p, and having 5 to 11 bases is disclosed. The pharmaceutical composition can inhibit a protein expression of an influenza virus.
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