Tricyclic inhibitors of poly(ADP-ribose) polymerases
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United States of America Patent
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Dec 17, 2002
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Jan 10, 2000
filing date -
Jan 11, 1999
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Abstract
Compounds of the formula below are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapuetics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and nuerodegenerative disease. ##STR1## As cancer therapuetics, the compounds of the invention may be used, e.g., in combination with cytotoxic agents and/or radiation.
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