Mx-1 conditionally immortalized cells

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United States of America Patent

PATENT NO 6495364
SERIAL NO

09801237

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Abstract

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This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the BAO with ECM molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination.

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Patent Owner(s)

Patent OwnerAddress
NEUROTECH USA INC900 HIGHLAND CORPORATE DRIVE BUILDING #1 SUITE 101 CUMBERLAND RI 02864

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hammang, Joseph P Barrington, RI 36 2399
Messing, Albee Madison, WI 5 52

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