Channel forming toxins as antiviral agents
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United States of America Patent
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Dec 17, 2002
Grant Date -
Jan 31, 2002
app pub date -
Jan 12, 2001
filing date -
Apr 9, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The infectivity of a population of enveloped viruses which comprise a glycosylphosphatidylinositol-anchored protein in their membrane can be reduced by employing certain toxins such as aerolysin, alpha toxin of Clostridium septicum, or enterolobin. Toxins which bind to glycosylphosphatidylinositol-anchored proteins inactivate such viruses. The toxins can be used to produce attenuated viral vaccines, to purge blood products, cells, or tissues of such viruses, and to detect viruses in samples.
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