Treatment of myeloma bone disease with proteasomal and NF-.kappa.B activity inhibitors
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United States of America Patent
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Dec 10, 2002
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N/A
app pub date -
Apr 9, 1999
filing date -
Apr 9, 1999
priority date (Note) -
Expired
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Abstract
The present invention involves the identification and use of compositions for treating myeloma bone disease. The compositions inhibit proteasomal activity and decrease the activity of the transcription factor NF-.kappa.B. Assessment of a candidate compound for its ability to inhibit production or activity of proteasomal enzymes or NF-.kappa.B provides a useful means to identify agents to treat myeloma bone disease.
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