Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions
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United States of America Patent
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Dec 3, 2002
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N/A
app pub date -
Mar 3, 2000
filing date -
Mar 5, 1999
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Abstract
A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are .alpha..sub.1 -antitrypsin and synthetic drugs mimicking some or all of the actions of .alpha..sub.1 -antitrypsin.
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