Methods and apparatus for template capture and normalization for submicroliter reaction
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United States of America Patent
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Dec 3, 2002
Grant Date -
N/A
app pub date -
Aug 2, 2000
filing date -
Aug 2, 1999
priority date (Note) -
Expired
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Abstract
Methods for preparing nanoscale reactions using nucleic acids are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and the reaction is performed directly within the capillary. Alternatively, the saturably bound nucleic acid is eluted, dispensing a metered amount of nucleic acid for subsequent reaction in a separate chamber. Devices for effecting the methods of the invention and a system designed advantageously to utilize the methods for high throughput nucleic acid sequencing reactions are also provided.
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