Pancreatic .beta. cell hexokinase transgene
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United States of America Patent
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Nov 26, 2002
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Dec 17, 1993
filing date -
Dec 17, 1993
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Abstract
A transgenic animal containing germ cells and somatic cells which contain a non-native recombinant gene which codes upon expression hexokinase capable of expressing hexokinase at significantly increased levels for study of the role of hexokinase in diabetes and other diseases. When these transgenic animals were exposed to a calmodulin stimulated model of diabetes increased levels of hexokinase activity were able to promote insulin secretion thereby reducing glucose levels in blood and transiently reduce the effects of diabetes.
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