Fab'-epitope complex from HIV-1 cross-neutralizing monoclonal antibody 2F5
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United States of America Patent
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Nov 19, 2002
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N/A
app pub date -
Apr 13, 1999
filing date -
Apr 13, 1999
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Abstract
The crystal structure of the Fab' fragment of Mab 2F5, a potent neutralizer of both laboratory strains and primary clinical isolates of most clades of HIV-1, both uncompleted and completed with the largely conserved peptide sequence ELDKWAS of the viral envelope protein gp41, has been elucidated and the characteristics of peptide-protein interactions determined. Having regard to such determination, the peptide-mimetics are constrained in the three-dimensional structure to provide an increased immunogenicity to the epitope sequence.
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