Matrix metalloproteinase inhibitors
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United States of America Patent
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Nov 19, 2002
Grant Date -
N/A
app pub date -
Mar 10, 1999
filing date -
Jul 10, 1997
priority date (Note) -
Expired
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Abstract
A compound, which is an amine derivative of formula (I) wherein W is --CNHOH or --COOH: R.sub.1 and R.sub.2 are each hydrogen or an organic residue, R.sub.3 is an organic group, Q is a secondary or tertiary acyclic or cyclic amido group, and the pharmaceutically acceptable salts, solvates and hydrates thereof, are inhibitors of matrix metalloproteinases (MMPs) and of the release of tumor necrosis factor-alpha (TNF) from cells. They are therefore useful in the prevention, control and treatment of diseases in which MMPs or TNF are involved, especially tumoral and inflammatory diseases. Processes for their preparation and pharmaceutical compositions containing them are also described. ##STR1##
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