Temperature sensitive gel for sustained delivery of protein drugs
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United States of America Patent
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Nov 19, 2002
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N/A
app pub date -
Jan 15, 1999
filing date -
Jul 12, 1996
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Abstract
Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having thermal gelation properties in which is incorporated a discrete suspension of at least one biologically active macromolecular polypeptide which retains greater than 90 percent of its biological activity. Furthermore, the concentration of the macromolecular polypeptide is greater than 0.5 percent by weight of the composition.
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