Two-step conversion of protected taxane ester to paclitaxel
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United States of America Patent
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Nov 12, 2002
Grant Date -
N/A
app pub date -
Apr 25, 2001
filing date -
Apr 25, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to a method of producing paclitaxel from a protected coupled ester compound having a formula: ##STR1## wherein P.sub.1 is a hydrogenatable protecting group, comprising the steps of deprotecting the 7-O-position, 3'-N-position and 2'-O-position thereof in the presence of an acid to form a first intermediate compound having a formula: ##STR2## wherein HA is said acid, and benzoylating the first intermediate compound at the 3'-N-position thereby to produce paclitaxel.
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