Heterocyclic benzenesulphonamide compounds as bradykinine antagonists
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United States of America Patent
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Nov 12, 2002
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Jul 24, 2001
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Feb 26, 1999
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Abstract
The invention concerns compounds selected among the group consisting of (i) compounds of formula (I) wherein: Het1 represents a nitrogenous heterocycle with 5 apices, in particular imidazole, pyrazole, or triazole; Het2 represents a nitrogenous heterocycle with 4, 5 or 6 apices, selected among the heterocycles: (II) wherein R.sub.1 and R.sub.2 are defined as mentioned in the description; and (ii) their additive salts. The invention also concerns the method for preparing said compounds and their use in therapy, in particular for treating pathologies involving bradykinine. ##STR1##
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