Importance

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Abstract

Compounds of formula (I) or salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethoxy, nitro, cyano, SO.sub.2 R.sub.2 or COR.sub.2 wherein R.sub.2 represents hydroxy, methoxy, amino, alkylamino or dialkylamino; m is zero or an integer 1 or 2; R.sub.1 represents cyano or the group (CH.sub.2)nCN, --CH.dbd.CHR.sub.3, CH.sub.2)nNHCOCH.sub.2 R.sub.4 or O(CH.sub.2)pNR.sub.5 R.sub.6 ; R.sub.3 represents cyano or the group COR.sub.7 ; R.sub.4 represents alkoxy or a group NHCOR.sub.8 ; R.sub.5 and R.sub.6 each represent independently hydrogen or alkyl, or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached represent a heterocyclic group, or R.sub.5 is hydrogen and R.sub.6 is the group COR.sub.9 ; R.sub.7 represents an alkoxy, amino or hydroxyl group; R.sub.8 represents a hydrogen atom or optionally substituted alkyl, alkoxy, aryl, or heterocyclic group; R.sub.9 is the group R.sub.8 or the group NR.sub.10 R.sub.11 wherein R.sub.10 represents hydrogen or alkyl group; R.sub.11 represents optionally substituted alkyl, aryl, heterocyclic or cycloalkyl group; n is zero or an integer from 1 to 4, p is an integer from 2 to 4, processes for their preparation and to their use in medicine. ##STR1##

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First Claim