Catalytic antibodies which hydrolyze primary amides and methods for eliciting and use of such antibodies
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United States of America Patent
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Nov 12, 2002
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N/A
app pub date -
Sep 8, 1995
filing date -
Apr 23, 1993
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Expired
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Abstract
Described and claimed are compounds of the formula ##STR1## wherein: Y is a polypeptide, R.sub.1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C.sub.1-21 alkyl, alkene, or alkyne group, R.sub.2 is a side chain of a naturally occuring amino acid, and X is ##STR2## Such compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described and claimed are methods employing the compounds and antibodies.
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