Discalamide compounds and their use as anti-proliferative agents
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United States of America Patent
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Nov 5, 2002
Grant Date -
Feb 7, 2002
app pub date -
Apr 16, 2001
filing date -
Apr 14, 2000
priority date (Note) -
Expired
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Abstract
The subject invention provides novel biologically active compounds which are useful for inhibiting cellular proliferation. Because of the biological activity of these compounds, they can be used for immunomodulation and/or treating cancer. In a preferred embodiment, the novel compounds, compositions and methods of use of the subject invention can advantageously be used to inhibit the growth of tumor cells in a mammalian host. More particularly, the subject compounds can be used for inhibiting in a human the growth of tumor cells, including cells of breast, colon, CNS, ovarian, renal, prostate, bone, gastrointestinal, stomach, testicular, or lung tumors, as well as human leukemia or melanoma cells. Specifically exemplified are discalamides A and B.
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