Sulfonamidomethyl phosphonate inhibitors of beta-lactamase
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United States of America Patent
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Oct 29, 2002
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N/A
app pub date -
Jul 5, 2000
filing date -
Jul 6, 1999
priority date (Note) -
Expired
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Abstract
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel .beta.-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic .beta.-lactamase inhibitors presently available, and which do not require a .beta.-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
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