METHOD AND LONG-TERM STABLE BICARBONATE-CONTAINING DILUENT COMPOSITION, AND STORAGE MEANS THEREFOR, FOR REDUCING OR REVERSING AERATION INDUCED CELL SHRINKAGE AND STORAGE INDUCED CELL SWELLING OF A WHOLE BLOOD SAMPLE
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United States of America Patent
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Oct 22, 2002
Issued Date -
N/A
app pub date -
Mar 28, 2001
filing date -
Apr 4, 2000
priority date (Note) -
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Abstract
The invention provides a bicarbonate-containing, crosslinker-free reagent composition which reverses and/or reduces sample handling effects, such as aeration-induced shrinkage and storage-induced swelling of cells in a whole blood sample, particularly for a blood sample requiring repeated sampling and/or subjected to long-term storage. The reagent composition serves as a diluent medium for a blood sample, or an aliquot or portion thereof. The pH of the reagent is in the range of about 7.2 to about 7.5, preferably 7.3. The stability of the pH 7.2-7.5 bicarbonate-containing reagent over time is maintained by storing the reagent in a flexible collapsible container which is impermeable to carbon dioxide and is comprised of a multilayered flexible material, preferably plastic, and attachable to a hematology analyzer.
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