Clostripain catalyzed amidation of peptides
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United States of America Patent
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Oct 8, 2002
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N/A
app pub date -
Dec 16, 1998
filing date -
Nov 6, 1998
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Expired
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Abstract
The invention provides a method of producing a polypeptide having a C-terminal .alpha.-carboxamide group. It particularly concerns an enzymatic modification of selected substrate polypeptides which result in cleavage of the substrate polypeptide to form a product peptide with a C-terminal arginine residue having an .alpha.-carboxamide group (C-terminal 'Arg-NH.sub.2 '). The method includes contacting an aqueous-based solution including (i) ammonia reagent and (ii) the substrate polypeptide with (iii) clostripain.
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