Three-step conversion of protected taxane ester to paclitaxel
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United States of America Patent
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Sep 17, 2002
Grant Date -
N/A
app pub date -
Apr 25, 2001
filing date -
Apr 25, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to a method of producing paclitaxel from a protected coupled ester compound having a formula: ##STR1## wherein P.sub.1 is a hydrogenatable protecting group, comprising deprotecting the 7-O-position and 3'-N-position of the protected coupled ester compound to form a first intermediate compound, benzoylating the first intermediate compound at the 3'-N-position thereby to form a second intermediate compound, and deprotecting the second intermediate compound by replacing P.sub.1 with hydrogen in the presence of an acid. The present invention also provides chemical compounds useful in the production of paclitaxel.
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