Purification of antithrombin-III-.alpha. and .beta.
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United States of America Patent
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Sep 17, 2002
Grant Date -
Oct 25, 2001
app pub date -
Jan 19, 2001
filing date -
Jan 21, 2000
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Abstract
PROTEIN PURIFICATION I The invention relates to processes for preparation of substantially pure antithrombin-III (AT-III), the antithrombin isoforms AT-III.alpha. and AT-III.beta.; and/or histidine-rich glycoprotein (HRGP). The processes comprise separating the said proteins on a cation exchange gel wherein the cation exchanger group is attached to the gel matrix via a linear polymer chain.
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