Bi-or multifunctional molecules based on a dendroaspin scaffold
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United States of America Patent
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Sep 17, 2002
Grant Date -
N/A
app pub date -
Sep 20, 1999
filing date -
Mar 20, 1997
priority date (Note) -
Expired
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Abstract
Dendroaspin, a polypeptide neurotoxin analogue is modified by recombinant DNA techniques, particularly 'loop grafting' to provide a modified polypeptide. The modified polypeptide is constructed so as to retain dendroaspin activity, for example, platelet adhesion to fibrinogen, in addition to possessing one or more further biological or biochemical activities not native to dendroaspin, for example, platelet derived growth factor (PDGF) activity or hirudin activity.
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