Molecules associated with the human suppressor of fused gene
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United States of America Patent
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Sep 10, 2002
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N/A
app pub date -
Aug 21, 2000
filing date -
Dec 19, 1997
priority date (Note) -
Expired
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Abstract
The present invention relates to proteins, polypeptides and nucleotides related to the human homologue of the Drosophila suppressor of fused gene, which is involved in the transduction of signals in the HH-PTC pathway. The invention also relates to antibodies raised against the polypeptides according to the invention. The molecules according to the present invention are useful in diagnostic and therapeutic methods relating to conditions associated with defects in said pathway, especially certain malformations and cancer. Other fields of application of the molecules according to the invention are e.g. studies of embryonic development, gene transcription and tissue repair.
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